与重复注射修饰的聚肌苷酸-聚胞苷酸复合物相关的全身代谢改变。
Systemic metabolic alterations associated with repeated injections of a modified polyriboinosinic-polyribocytidylic acid complex.
作者信息
Powanda M C, Sammons M L, Stephen E L
出版信息
Antimicrob Agents Chemother. 1977 Nov;12(5):602-5. doi: 10.1128/AAC.12.5.602.
Abstract
Polyriboinosinic acid-polyribocytidylic acid complexed with poly-1-lysine and injected intramuscularly into rats (0.3 or 3.0 mg/kg) produced fever, altered leukocyte count, slightly depressed plasma zinc, increased amino acid uptake into liver, and increased plasma acute-phase globulins two- to threefold. It is suggested that these systemic metabolic alterations are indicative of a mild inflammatory response to this drug. The metabolic alterations may have to be taken into consideration when polyriboinosinic acid-polyribocytidylic acid complexed with poly-1-lysine is used in therapy.
摘要
与聚 -1 -赖氨酸复合的聚肌苷酸 - 聚胞苷酸经肌肉注射到大鼠体内（0.3或3.0毫克/千克）后，可引起发热、白细胞计数改变、血浆锌略有降低、肝脏对氨基酸的摄取增加以及血浆急性期球蛋白增加两到三倍。提示这些全身代谢改变表明对该药物有轻度炎症反应。当使用与聚 -1 -赖氨酸复合的聚肌苷酸 - 聚胞苷酸进行治疗时，可能必须考虑这些代谢改变。
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