秀丽小克银汉霉对萘的代谢
Metabolism of naphthalene by Cunninghamella elegans.
作者信息
Cerniglia C E, Gibson D T
出版信息
Appl Environ Microbiol. 1977 Oct;34(4):363-70. doi: 10.1128/aem.34.4.363-370.1977.
Abstract
Cunninghamella elegans grown on Sabouraud dextrose broth in the presence of naphthalene produced six metabolites. Each product was isolated and identified by conventional chemical techniques. The major metabolites were 1-naphthol (67.9%) and 4-hydroxy-1-tetralone (16.7%). Minor products isolated were 1,4-naphthoquinone (2.8%), 1,2-naphthoquinone (0.2%), 2-naphthol (6.3%), and trans-1,2-dihydroxy-1,2-dihydronaphthalene (5.3%). C. elegans oxidized both 1-naphthol and 1,4-naphthoquinone to 4-hydroxy-1-tetralone. The results suggest that C. elegans oxidizes naphthalene by a sequence of reactions similar to those reported for the mammalian metabolism of this hydrocarbon.
摘要
在含有萘的沙氏葡萄糖肉汤中生长的雅致小克银汉霉产生了六种代谢产物。每种产物都通过传统化学技术进行了分离和鉴定。主要代谢产物是1-萘酚（67.9%）和4-羟基-1-萘满酮（16.7%）。分离出的次要产物有1,4-萘醌（2.8%）、1,2-萘醌（0.2%）、2-萘酚（6.3%）和反式-1,2-二羟基-1,2-二氢萘（5.3%）。雅致小克银汉霉将1-萘酚和1,4-萘醌都氧化为4-羟基-1-萘满酮。结果表明，雅致小克银汉霉通过一系列类似于哺乳动物对这种碳氢化合物代谢所报道的反应来氧化萘。
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