Baba T, Morisita K, Sakata J, Ito T, Hachiro Y, Kazui T, Abe A, Komatu S
Second Department of Surgery, School of Medicine, Sapporo Medical University, Japan.
Artif Organs. 1997 Jul;21(7):779-81. doi: 10.1111/j.1525-1594.1997.tb03741.x.
In cardiovascular operations, we have usually used heparin-coated cardiopulmonary bypass circuits with low systemic heparinization. Three types of heparin-coated cardiopulmonary bypass circuits are available in Japan: 2 of the 3 have covalent heparin bonding, and the other has ionic heparin bonding. We studied these circuits in ex vivo experiments to explore which were the best in terms of biocompatibility. In this study we compared the Carmeda system (Medtronic) and the Capiox system (Terumo) with covalent heparin bonding, and the Duraflo-II (Baxter) with ionic heparin bonding, evaluating them in ex vivo experiments. They were primed with fresh human blood, and we studied and compared the platelet counts, fibrinogen, D-dimmer, beta-thioguanine (TG), thrombin-antithrombin complex (TAT), and C3a and C4a of each of them. Additional research will be presented in the future.
在心血管手术中，我们通常使用低全身肝素化的肝素涂层体外循环回路。日本有三种类型的肝素涂层体外循环回路：其中两种采用共价肝素键合，另一种采用离子肝素键合。我们在体外实验中研究了这些回路，以探索哪种在生物相容性方面最佳。在本研究中，我们比较了采用共价肝素键合的卡美达系统（美敦力公司）和卡普iox系统（泰尔茂公司），以及采用离子肝素键合的杜拉弗洛-II（百特公司），并在体外实验中对它们进行评估。用新鲜人血对它们进行预充，我们研究并比较了它们各自的血小板计数、纤维蛋白原、D-二聚体、β-硫鸟嘌呤（TG）、凝血酶-抗凝血酶复合物（TAT）以及C3a和C4a。未来将展示更多研究成果。
