Grennan D M, Bunn C, Hughes G R, Buchanan W W, Dick W C
Ann Rheum Dis. 1977 Oct;36(5):442-7. doi: 10.1136/ard.36.5.442.
Antibodies to the ribonucleoprotein (RNP) component of extractable nuclear antigen were measured in patients with systemic lupus erythematosus (SLE) and other connective tissue subgroups by counterimmunoelectrophoresis. Antibodies to RNP were found in the sera of 32% of patients with a primary diagnosis of SLE, 29% of patients with features of SLE and erosive joint disease, none of 9 scleroderma patients, and in 75% of 8 patients with features of SLE and scleroderma. In the SLE patients overall there was an increased frequency of sclerodactyly and severe Raynaud's phenomenon in the patients with antibodies to RNP but no association of antibodies to RNP was found with the presence of erosive joint disease, Sjögren's syndrome, or the absence of renal disease in these patients.
采用对流免疫电泳法检测了系统性红斑狼疮（SLE）患者及其他结缔组织亚组患者血清中可提取核抗原的核糖核蛋白（RNP）成分抗体。在初诊为SLE的患者中，32%的患者血清中检测到RNP抗体；有SLE特征及侵蚀性关节病的患者中，29%检测到该抗体；9例硬皮病患者中均未检测到；8例有SLE和硬皮病特征的患者中，75%检测到该抗体。总体而言，在SLE患者中，存在RNP抗体的患者出现指（趾）硬皮病和严重雷诺现象的频率增加，但未发现RNP抗体与这些患者的侵蚀性关节病、干燥综合征或无肾脏疾病之间存在关联。
