Cafagna D, Ponte E
Prima Divisione di Medicina Generale, USL n. 1 Triestina, Ospedale di Cattinara, Trieste,
Minerva Cardioangiol. 1997 Jan-Feb;45(1-2):49-55.
The positive correlation existing between hyperhomocysteinemia and atherosclerosis has firmly been established through data derived from numerous epidemiologic and experimental observations as well as from intervention trials. Although most of the clinical data have been obtained in relation to coronary heart disease, hyperhomocysteinemia is also observed in patients with cerebral and peripheral arterial occlusive disease or peripheral venous thrombosis. The prevalence of the heterozygous state is today estimated about 1 to 2 percent of the population. Mild and moderate hyperhomocysteinemia have recently been proposed as an additional and independent risk factor for vascular disease. In this review we therefore describe recent findings about the pathogenesis of hyperhomocysteinemia and their implications for optimal drug therapy.
通过大量流行病学、实验观察以及干预试验所获得的数据，已确凿证实高同型半胱氨酸血症与动脉粥样硬化之间存在正相关关系。尽管大多数临床数据是关于冠心病的，但在患有脑和外周动脉闭塞性疾病或外周静脉血栓形成的患者中也观察到了高同型半胱氨酸血症。如今估计杂合子状态的患病率约为人群的1%至2%。轻度和中度高同型半胱氨酸血症最近被认为是血管疾病的一个额外且独立的危险因素。因此，在本综述中，我们描述了关于高同型半胱氨酸血症发病机制的最新发现及其对最佳药物治疗的影响。
