Sánchez Rodríguez A, Sánchez Fuentes D, Chimpén Ruiz V, Martín Oterino J A, Araoz Sánchez P, de Portugal Alvarez J
Servicio de Medicina Interna, Hospital Clínico Universitario, Salamanca.
Rev Clin Esp. 1997 Feb;197(2):96-9.
A clinical and therapeutical study of 47 patients with the diagnosis of acute pancreatitis is reported. According to Ranson's criteria patients were initially classified as suffering from mild (28) and severe (18) acute pancreatitis. Twenty-eight, 11, 7 and 1 patients had biliary, alcoholic, idiopathic and neoplastic causes, respectively, of their conditions. The classification of episodes was made on the basis of clinical manifestations, biologic investigations, and imaging diagnosis, and is shown in the corresponding tables. The therapeutic profile was a randomized double-blind study: perfused somatostatin (SS) versus placebo (P) (physiologic saline 0.9%). The administration of somatostatin in perfusion (250 mcg/h/48 hours) did not improve significantly the parameters used to score the severity, although the mortality rate decreased significantly (p < 0.05) in the group of patients with the severe form of the disease.
本文报告了对47例诊断为急性胰腺炎患者的临床及治疗研究。根据兰森标准，患者最初被分为轻度（28例）和重度（18例）急性胰腺炎。其中28例、11例、7例和1例患者的病因分别为胆源性、酒精性、特发性和肿瘤性。根据临床表现、生物学检查和影像学诊断对发作进行分类，并在相应表格中显示。治疗情况为随机双盲研究：灌注生长抑素（SS）与安慰剂（P）（0.9%生理盐水）对比。尽管在重症患者组中死亡率显著降低（p<0.05），但以250 mcg/h的速度灌注生长抑素48小时，并未显著改善用于评估严重程度的参数。
