Williamson K M, Cotton B R, Smith G
Department of Obstetrics and Gynaecology, City Hospital, Nottingham.
Br J Anaesth. 1997 Jun;78(6):675-7. doi: 10.1093/bja/78.6.675.
In this preliminary randomized study, we have measured pain scores at rest and on movement, 24 and 48 h after operation in 19 control patients, who received 50 ml of saline i.p., and in 20 test patients, in whom 50 ml of saline solution containing lignocaine 200 mg and adrenaline 1:500,000 were instilled into the peritoneal cavity after total abdominal hysterectomy. We found that there was no difference in linear analogue scores for nausea, pain on movement or morphine consumption after operation between the two groups, but pain scores at rest were significantly lower in the lignocaine group at 24 and 48 h compared with the saline group. In the lignocaine group, blood sampling over a 3-h period revealed a mean maximum serum concentration of 0.4 microgram ml-1 at 3 h and a highest concentration in any patient of 0.87 microgram ml-1.
在这项初步随机研究中，我们对19名接受腹腔内注射50毫升生理盐水的对照患者以及20名试验患者进行了术后24小时和48小时静息及活动时疼痛评分的测量。试验组患者在全腹子宫切除术后向腹腔内注入50毫升含200毫克利多卡因和1:500,000肾上腺素的生理盐水溶液。我们发现，两组患者术后恶心、活动时疼痛或吗啡用量的线性模拟评分没有差异，但利多卡因组在24小时和48小时静息时的疼痛评分与生理盐水组相比显著更低。在利多卡因组，3小时的血样采集显示，3小时时血清平均最大浓度为0.4微克/毫升，任何一名患者的最高浓度为0.87微克/毫升。
