Baroncelli S, Barry P A, Capitanio J P, Lerche N W, Otsyula M, Mendoza S P
California Regional Primate Research Center, University of California, Davis 95616-8542, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1997 May 1;15(1):5-15. doi: 10.1097/00042560-199705010-00002.
Antibody titers to rhesus cytomegalovirus (RhCMV) were prospectively analyzed over a period of 68 weeks in a longitudinal serosurvey of 17 RhCMV-seropositive rhesus macaques (Macaca mulatta) experimentally coinfected with simian immunodeficiency virus (SIV). These were compared with anti-RhCMV titers in 18 animals that were also naturally infected with RhCMV but not infected with SIV. Fluctuations in anti-RhCMV antibody titers were observed within 5 weeks of SIV inoculation, and two distinct patterns of RhCMV antibody response were observed in SIV-infected animals. Animals showing a progressive decline in anti-RhCMV immunoglobulin G (IgG) exhibited the most rapid disease progression, coincident with low anti-SIV and anti-tetanus toxoid IgG responses, high levels of p27 antigen in the plasma, and short survival. Animals exhibiting a more stable CMV-specific response after SIV inoculation had the least rapid disease course. Anti-RhCMV antibody titers in SIV-uninfected animals remained relatively stable during the period of study. Evidence that preinoculation immunologic measures predicted postinoculation outcome was equivocal.
在一项针对17只实验性同时感染猿猴免疫缺陷病毒（SIV）的恒河猴巨细胞病毒（RhCMV）血清阳性恒河猴（猕猴）的纵向血清学调查中，对RhCMV的抗体滴度进行了为期68周的前瞻性分析。将这些结果与18只同样自然感染RhCMV但未感染SIV的动物的抗RhCMV滴度进行了比较。在接种SIV的5周内观察到抗RhCMV抗体滴度的波动，并且在感染SIV的动物中观察到两种不同的RhCMV抗体反应模式。抗RhCMV免疫球蛋白G（IgG）呈进行性下降的动物疾病进展最快，这与低抗SIV和抗破伤风类毒素IgG反应、血浆中高水平的p27抗原以及较短的生存期相一致。在接种SIV后表现出更稳定的CMV特异性反应的动物疾病进程最慢。在研究期间，未感染SIV的动物的抗RhCMV抗体滴度保持相对稳定。接种前免疫指标能否预测接种后结果的证据并不明确。
