Johns J M, Noonan L R, Zimmerman L I, Li L, Pedersen C A
Department of Psychiatry, University of North Carolina, Chapel Hill 27599-7096, USA.
Dev Neurosci. 1997;19(4):368-74. doi: 10.1159/000111234.
Pregnant rats were treated with 30 mg/kg per day cocaine or normal saline either throughout gestation (GD 1-20, cocaine and saline withdrawal) or throughout the gestation and continuing into lactation for 10 days postpartum (cocaine and saline nonwithdrawal). All cocaine-treated dams exhibited more disruptions in the onset of maternal behavior (retrieval, licking, crouching) and were more aggressive (threats and attacks) towards an intruder on postpartum day 6 than saline-treated dams. There were no significant differences in these behaviors between withdrawn and nonwithdrawn cocaine-treated dams. These findings indicate that changes in maternal behavior following chronic moderate cocaine treatment are not simply the result of withdrawal from cocaine treatment following gestation and that other possible mechanisms should be examined.
将怀孕大鼠在整个妊娠期（妊娠第1至20天，可卡因和生理盐水戒断组）或整个妊娠期并持续至产后10天哺乳期（可卡因和生理盐水非戒断组）每天用30毫克/千克可卡因或生理盐水进行处理。与生理盐水处理的母鼠相比，所有接受可卡因处理的母鼠在产后第6天表现出更多母性行为（找回、舔舐、蹲伏）起始方面的紊乱，并且对入侵者更具攻击性（威胁和攻击）。在戒断和未戒断的可卡因处理母鼠之间，这些行为没有显著差异。这些发现表明，慢性适度可卡因处理后母性行为的变化不仅仅是妊娠后可卡因处理戒断的结果，还应研究其他可能的机制。
