de Freitas R M, Faria M de A, Alves S N, de Melo A L
Grupo Interdepartamental de Estudos sobre Esquistossomose (GIDE)/Departamento de Parasitologia, Universidade Federal de Minas Geraix, Belo Horizonte, Brasil.
Rev Inst Med Trop Sao Paulo. 1996 Jul-Aug;38(4):293-7. doi: 10.1590/s0036-46651996000400010.
The effects of ivermectin, a semi-synthetic drug widely used for treatment of livestock parasite diseases, were observed on Culex quinquefasciatus larvae. Toxic effects and mortality evaluation were carried out after 5, 15, 30 and 60 minutes of exposure to 1, 5 or 10 ppm of ivermectin solutions. Observations were made 24 and 48 hours after the beginning of the experiment, and loss of mobility, progressive paralysis and high mortality of larvae were recorded. The observed effects of ivermectin on the mosquito larvae is probably correlated with chloride channel activation on cell membranes.
观察了广泛用于治疗家畜寄生虫病的半合成药物伊维菌素对致倦库蚊幼虫的影响。在接触1、5或10 ppm伊维菌素溶液5、15、30和60分钟后进行毒性作用和死亡率评估。在实验开始后24小时和48小时进行观察，记录幼虫活动能力丧失、进行性麻痹和高死亡率。伊维菌素对蚊虫幼虫的观察到的影响可能与细胞膜上氯离子通道的激活有关。
