Ray D E, Hawgood B J
Aviat Space Environ Med. 1977 Nov;48(11):1046-50.
The electroretinogram (ERG) was measured in lightly anaesthetised rats exposed to 4-7 atm O2 until death. An initial increase and later decrease in amplitude with increase in latency was seen which, although not consistently related to the appearance of seizures characteristically seen above 4.5 atm 02, appeared closely linked to systemic factors. A fall in respiration rate always preceded the fall of the ERG, and apnoea preceded ERG extinction. When blood pressure and ERG were measured in two comparable groups of rats exposed to 5.76 atm O2, both records showed similar time courses. The cerebral visual evoked response (VER) was measured at 5.76 atm O2 simultaneously with the ERG. The later VER waves showed a degree of enhancement at the time of seizures, but otherwise amplitude and waveform were maintained until late in toxicity. EEG spiking gave the earliest indication of toxicity, and it is concluded that the primary projection to the rat visual cortex is comparatively resistant to high-pressure oxygen.
在轻度麻醉的大鼠中测量视网膜电图（ERG），将其暴露于4-7个大气压的氧气中直至死亡。随着潜伏期增加，最初振幅增加，随后降低，这一现象虽与4.5个大气压以上典型出现的癫痫发作并无始终关联，但似乎与全身因素密切相关。呼吸频率下降总是先于ERG下降，呼吸暂停先于ERG消失。当在两组暴露于5.76个大气压氧气的可比大鼠中测量血压和ERG时，两项记录显示出相似的时间进程。在5.76个大气压氧气下同时测量大脑视觉诱发电位（VER）和ERG。后期VER波在癫痫发作时显示出一定程度的增强，但在毒性晚期之前，振幅和波形均保持不变。脑电图尖峰是毒性的最早迹象，得出的结论是，大鼠视觉皮层的主要投射对高压氧具有相对抗性。
