Hellwig J, Freudenberger H, Jäckh R
Department of Toxicology, BASF Aktiengesellschaft, Ludwigshafen, Germany.
Food Chem Toxicol. 1997 May;35(5):501-12. doi: 10.1016/s0278-6915(97)00008-2.
Several phthalate esters with alcohol moieties ranging from C5-C10 chains were investigated for prenatal toxicity in 10 rats per group after gavage administration of 0, 40, 200 and 1000 mg/kg/day from gestation day 6 to 15. At 1000 mg/kg di(2-ethylhexyl) phthalate showed clear foetotoxicity, embryolethality and teratogenicity. No significant effects were recorded at 40 and 200 mg/kg. Di-711-phthalate, a phthalic ester with linear components and a predominantly alpha-methyl branching type, and di-isopentylphthalate showed a very similar spectrum of effects. Interestingly, the alcohol moiety of di-711-phthalate, 711-alcohol was developmentally inactive in a previous experiment. Di-iso-decylphthalate and three types of di-iso-nonylphthalate showed foetal effects of borderline significance at 1000 mg/kg/day.
研究了几种醇部分碳链长度在C5 - C10之间的邻苯二甲酸酯对产前毒性的影响。从妊娠第6天到第15天，每组10只大鼠经口灌胃给予0、40、200和1000毫克/千克/天的剂量。在1000毫克/千克剂量下，邻苯二甲酸二（2 - 乙基己基）酯表现出明显的胚胎毒性、胚胎致死性和致畸性。在40和200毫克/千克剂量下未记录到显著影响。二-711-邻苯二甲酸酯（一种具有线性成分和主要为α-甲基支链类型的邻苯二甲酸酯）和邻苯二甲酸二异戊酯表现出非常相似的效应谱。有趣的是，在之前的实验中，二-711-邻苯二甲酸酯的醇部分711-醇在发育方面无活性。邻苯二甲酸二异癸酯和三种类型的邻苯二甲酸二异壬酯在1000毫克/千克/天剂量下表现出具有临界显著性的胎儿效应。
