Singh N, Sundar S, Williams F, Curran M D, Rastogi A, Agrawal S, Middleton D
Department of Biochemistry, Central Drug Research Institute, Lucknow, India.
Trop Med Int Health. 1997 May;2(5):468-71.
HLA has been shown to be associated with many diseases. To find out whether host genetic factors like the HLA are involved in susceptibility to kala-azar (visceral leishmaniasis) in India, we formulated an association study with genetically related controls. All samples were typed by PCR SSOP (sequence specific oligonucleotide probes) for HLA class I (A and B) and class II (DR) antigens. The test of association we used was the transmission disequilibrium test (TDT). No significant evidence for association with any of the three HLA loci was obtained.
人类白细胞抗原（HLA）已被证明与多种疾病相关。为了探究像HLA这样的宿主遗传因素是否参与印度黑热病（内脏利什曼病）的易感性，我们开展了一项针对具有遗传相关性对照的关联研究。所有样本均通过聚合酶链反应-序列特异性寡核苷酸探针（PCR-SSOP）对HLAⅠ类（A和B）和Ⅱ类（DR）抗原进行分型。我们使用的关联检验方法是传递不平衡检验（TDT）。未获得与三个HLA基因座中任何一个相关的显著证据。
