Pierce G N, Russell J C
Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Winnipeg, MB, Canada.
Cardiovasc Res. 1997 Apr;34(1):41-7. doi: 10.1016/s0008-6363(97)00010-2.
Cardiovascular disease is a significant medical problem. The diabetic population is even more susceptible to cardiovascular complications and heart failure than non-diabetic patients. Atherosclerotic complications, a neuropathy and microvascular lesions have all been implicated causally in the accelerated cardiovascular disease during diabetes. However, one mechanism which may participate in the abnormalities in heart performance demonstrated during diabetes and may also contribute to heart failure in the diabetic is a derangement in the capacity of the myocardial cell to regulate its [Ca2+]. The purpose of this treatise is to identify the current controversies and conclusions available regarding the specific defects in Ca2+ flux thought to contribute to these cardiac defects during diabetes mellitus.
心血管疾病是一个重大的医学问题。糖尿病患者比非糖尿病患者更容易出现心血管并发症和心力衰竭。动脉粥样硬化并发症、神经病变和微血管病变都被认为是糖尿病期间心血管疾病加速发展的病因。然而，一种可能参与糖尿病期间心脏功能异常且可能导致糖尿病患者心力衰竭的机制是心肌细胞调节其[Ca2+]能力的紊乱。本论文的目的是确定目前关于Ca2+通量的特定缺陷的争议和结论，这些缺陷被认为会导致糖尿病期间的这些心脏缺陷。
