La Spada A R, Clark A W
Department of Laboratory Medicine, University of Washington Medical Center, Seattle 98195, USA.
Brain Pathol. 1997 Jul;7(3):877-80. doi: 10.1111/j.1750-3639.1997.tb00891.x.
At the beginning of this decade, the American Association of Neurology decided that the 1990's should be labelled “the decade of the brain” for expected advances in our understanding of neurological disorders and neuroscience. By the end of this decade, clinicians and researchers who work in the field of inherited neurological disorders might well remember the 1990's as “the decade of the trinucleotide repeat”. At the time of writing this introduction, eleven inherited neurological disorders have been found to be caused by expansions of trinucleotide repeats, and a twelfth trinucleotide repeat expansion mutation has been identified (6), although the gene containing this mutant triplet repeat has not been cloned to our knowledge (Table 1).
在本十年之初，美国神经病学协会决定，鉴于我们有望在神经疾病和神经科学认知方面取得进展，20世纪90年代应被称为“大脑的十年”。到本十年末，从事遗传性神经疾病领域工作的临床医生和研究人员很可能会将20世纪90年代铭记为“三核苷酸重复的十年”。在撰写本引言时，已发现11种遗传性神经疾病是由三核苷酸重复扩增引起的，并且已鉴定出第12种三核苷酸重复扩增突变（6），尽管据我们所知，包含此突变三联体重复的基因尚未被克隆（表1）。
