Santoso-Pham J C, Shelley E D, Shelley W B
Division of Dermatology, Medical College of Ohio, Toledo 43699-0008, USA.
Cutis. 1997 Jun;59(6):329-32.
Keratoacanthoma is a common skin tumor characterized by rapid growth of a smooth dome-shaped nodule with a central plug of keratin, usually followed by spontaneous involution. We report the case of a giant keratoacanthoma on the face that continued to spread peripherally for several months despite vigorous therapeutic intervention. Treatment with methotrexate (25 mg intramuscularly) and Kenalog (triamcinolone acetonide, 40 mg intramuscularly) weekly finally slowed and stopped the expanding, deforming tumor growth and induced involution.
角化棘皮瘤是一种常见的皮肤肿瘤，其特征为光滑的圆顶状结节迅速生长，中央有角质栓，通常随后会自行消退。我们报告一例面部巨大角化棘皮瘤病例，尽管进行了积极的治疗干预，但该肿瘤仍在外周持续扩散数月。每周使用甲氨蝶呤（25毫克肌肉注射）和康宁克通（曲安奈德，40毫克肌肉注射）治疗最终减缓并停止了不断扩大、变形的肿瘤生长，并促使其消退。
