酸性饮料（可口可乐）对伊曲康唑吸收的影响。
Influence of an acidic beverage (Coca-Cola) on the absorption of itraconazole.
作者信息
Jaruratanasirikul S, Kleepkaew A
机构信息
Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla, Thailand.
出版信息
Eur J Clin Pharmacol. 1997;52(3):235-7. doi: 10.1007/s002280050280.
OBJECTIVE
To evaluate the effectiveness of Coca-Cola in enhancing the absorption of itraconazole.
METHODS
Eight healthy volunteers were randomized to receive two treatment sequences in a two-way crossover design with a 1-week wash-out period separating each study treatment. Treatment 1, the control, consisted of 100 mg itraconazole with 325 ml water. Treatment II was identical to treatment I, except that itraconazole was administered with 325 ml of Coca-Cola (pH 2.5).
RESULTS
Serum itraconazole concentrations, after administration with Coca-Cola (treatment II), were higher than after administration with water (treatment I). The mean AUC was 1.12 vs 2.02 micrograms.h.m1-1, the mean Cmax was 0.14 vs 0.31 micrograms.m1-1 and the mean tmax was 2.56 vs 3.38 h in treatments I and II, respectively.
CONCLUSION
The absorption of itraconazole can be enhanced by Coca-Cola.
目的
评估可口可乐对伊曲康唑吸收的促进作用。
方法
8名健康志愿者按双向交叉设计随机接受两种治疗方案，每种治疗方案之间有1周的洗脱期。治疗1（对照）为100毫克伊曲康唑加325毫升水。治疗2与治疗1相同，只是伊曲康唑与325毫升可口可乐（pH值2.5）一同服用。
结果
服用可口可乐（治疗2）后血清伊曲康唑浓度高于服用水（治疗1）后。治疗1和治疗2的平均AUC分别为1.12和2.02微克·小时·毫升⁻¹，平均Cmax分别为0.14和0.31微克·毫升⁻¹，平均tmax分别为2.56和3.38小时。
结论
可口可乐可促进伊曲康唑的吸收。
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