Brodie M J, Moore M R, Thompson G G, Goldberg A, Low R A
Br J Obstet Gynaecol. 1977 Oct;84(10):726-31. doi: 10.1111/j.1471-0528.1977.tb12480.x.
An analysis is presented of the obstetric histories of 50 women with acute porphyria, comprising 39 with acute intermittent porphyria, 3 with variegate porphyria and 8 with hereditary coporporphyria. Fifty-four per cent of the women with acute intermittent porphyria had an acute attack of porphyria in pregnancy and/or the puerperium. Only one maternal death was recorded. One patient with variegate prophyria and two with hereditary coproporphyria had an attack related to pregnancy. The total fetal wastage was 13 per cent. The babies born to mothers with acute intermittent porphyria, who experienced an acute attack during pregnancy, were smaller than those in which no such attack occurred (P less than 0.001). In 13 non-porphyric primigravidae there was a rise in urinary excretion of delta-aminolaevulinic acid, porphobilinogen and coproporphyrin up to the 28th week of gestation. It is probable that pregnancy has some deleterious effects in acute prophyria but the prognosis of the porphyric pregnancy is much better than the literature suggests.
本文对50例急性卟啉病患者的产科病史进行了分析，其中包括39例急性间歇性卟啉病患者、3例杂合性卟啉病患者和8例遗传性粪卟啉病患者。54%的急性间歇性卟啉病女性在妊娠和/或产褥期发生了卟啉病急性发作。仅记录到1例孕产妇死亡。1例杂合性卟啉病患者和2例遗传性粪卟啉病患者发生了与妊娠相关的发作。总胎儿丢失率为13%。妊娠期间发生急性发作的急性间歇性卟啉病母亲所生的婴儿，比未发生此类发作的母亲所生的婴儿体重轻（P<0.001）。在13例非卟啉病初产妇中，直至妊娠28周，δ-氨基-γ-酮戊酸、卟胆原和粪卟啉的尿排泄量均有所增加。妊娠可能对急性卟啉病有一些有害影响，但卟啉病妊娠的预后比文献报道的要好得多。
