Schupf N, Zigman W, Kapell D, Lee J H, Kline J, Levin B
Laboratory of Epidemiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA.
J Intellect Disabil Res. 1997 Jun;41 ( Pt 3):264-7. doi: 10.1111/j.1365-2788.1997.tb00706.x.
We used the AAMR's Adaptive Behavior Scale to ascertain current menstrual status in a population-based sample of 157 women with Down's syndrome (DS) and 187 women with other intellectual disability, all 40 years of age or older. The age-adjusted likelihood of menopause was twice as high in women with DS syndrome as in women with other intellectual disability (OR = 2.3; 95% CI = 1.1-4.9). Treated thyroid conditions did not influence menstrual status and did not modify the relationship between DS and menstrual status. These findings support the hypothesis that women with DS experience menopause at an earlier age and that this may be associated with accelerated aging.
我们使用美国智力落后协会的适应性行为量表，在一个基于人群的样本中确定了157名唐氏综合征（DS）女性和187名其他智力残疾女性的当前月经状况，所有女性年龄均在40岁及以上。经年龄调整后，DS综合征女性绝经的可能性是其他智力残疾女性的两倍（优势比=2.3；95%置信区间=1.1-4.9）。接受治疗的甲状腺疾病不影响月经状况，也未改变DS与月经状况之间的关系。这些发现支持了以下假设：DS女性绝经年龄较早，这可能与加速衰老有关。
