Murata-Kamiya N, Kaji H, Kasai H
Department of Health Policy and Management, University of Occupational and Environmental Health, Kitakyushu, Japan.
Mutat Res. 1997 Jun 9;377(1):13-6. doi: 10.1016/s0027-5107(97)00016-x.
We have analyzed the types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium. A set of six strains, TA7001 to TA7006, was used to detect base-pair substitutions, and the TA98 strain was employed to detect frameshift mutations. Glyoxal did not induce mutations at A:T base pairs. The majority of the mutations induced by glyoxal were base-pair substitutions at G:C base pairs, and a small level of frameshift mutations was detected in the TA98 strain.
我们分析了乙二醛（一种主要的氧化性DNA损伤产物）在鼠伤寒沙门氏菌中诱导产生的突变类型。使用一组六个菌株（TA7001至TA7006）来检测碱基对替换，并用TA98菌株检测移码突变。乙二醛不会在A:T碱基对处诱导突变。乙二醛诱导产生的大多数突变是G:C碱基对处的碱基对替换，并且在TA98菌株中检测到少量的移码突变。
