Fischer E, Rafiei A, Bojcsev S
Department of Pharmacology, University Medical School, Pécs, Hungary.
Acta Physiol Hung. 1996;84(3):287-8.
Effect of hyperglycemia on the intestinal elimination of p-nitrophenol has been investigated in rats. Hyperglycemia was produced by a continuous i.v. infusion of glucose, p-nitrophenol was used as a model compound for the investigation of intestinal metabolism and excretion of drugs. Intestinal conjugation of p-nitrophenol with glucuronic acid did not change significantly in hyperglycemic rats, however, formation of sulfoconjugate of p-nitrophenol was enhanced by hyperglycemia. Sum of metabolites (p-nitrophenol glucuronide and sulfate) appeared in the intestinal lumen in hyperglycemic rats was similar to the total luminal appearance of these metabolites of control rats.
已在大鼠中研究了高血糖对肠道消除对硝基苯酚的影响。通过持续静脉输注葡萄糖诱导产生高血糖，对硝基苯酚用作研究药物肠道代谢和排泄的模型化合物。在高血糖大鼠中，对硝基苯酚与葡萄糖醛酸的肠道结合没有显著变化，然而，高血糖会增强对硝基苯酚硫酸共轭物的形成。高血糖大鼠肠腔中出现的代谢物（对硝基苯酚葡萄糖醛酸苷和硫酸盐）总和与对照大鼠这些代谢物的总肠腔出现量相似。
