Gagało I T, Hać E E, Korolkiewicz K Z, Matuszek M T, Szreder Z
Department of Pharmacology, Medical University of Gdansk, Poland.
Acta Physiol Hung. 1996;84(3):289-90.
Thermoregulatory responses after treatment with nitric oxide (NO) donor, sodium nitroprusside (SNP-3 mg/kg/h), or NO synthase inhibitor, NG-nitro-L-arginine methylester (L-NAME-100 mg/kg) were investigated in febrile rabbits (lipopolysaccharide E. coli-1 meg/kg). Pretreatment with SNP attenuated pyrogen fever as well as metabolic rate. L-NAME also inhibited postpyrogen increases in metabolism; however, this effect did not lead to antipyresis.
在发热兔（大肠杆菌脂多糖-1毫克/千克）中研究了用一氧化氮（NO）供体硝普钠（SNP-3毫克/千克/小时）或NO合酶抑制剂NG-硝基-L-精氨酸甲酯（L-NAME-100毫克/千克）治疗后的体温调节反应。用SNP预处理可减轻致热原性发热以及代谢率。L-NAME也抑制了热原后代谢的增加；然而，这种作用并未导致解热。
