Kovanecz I, Papp J G, Szekeres L
Department of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Acta Physiol Hung. 1996;84(3):297-8.
In the present study we tested the preconditioning effect of repeated beta adrenergic stress induced by Isoproterenol in chronically instrumented, conscious rabbits. We have found that at least 5 intravenous administrations of Isoproterenol, repeated at 10 min intervals, were necessary to induce a long-term cardiac adaptation manifested by a significant reduction of the harmful ischaemic changes due to cardiac stress 24 and 48 hours after preconditioning. These results suggest that a well-defined threshold level of the preconditioning stress is needed to trigger induction of metabolic changes leading to development of delayed and long-term cardiac adaptation.
在本研究中，我们对长期植入仪器的清醒家兔，测试了由异丙肾上腺素诱导的反复β肾上腺素能应激的预处理效应。我们发现，至少5次静脉注射异丙肾上腺素（每隔10分钟重复一次），对于诱导长期心脏适应性是必要的，这种适应性表现为在预处理后24小时和48小时，心脏应激导致的有害缺血性变化显著减少。这些结果表明，需要一个明确界定的预处理应激阈值水平，来触发导致延迟和长期心脏适应性发展的代谢变化的诱导。
