大鼠皮肤中隐神经逆行刺激诱发的微循环非肾上腺素能调节。
Non-adrenergic regulation of microcirculation evoked by antidromic stimulation of the saphenous nerve in the rat skin.
作者信息
Pintér E, Helyes Z, Pethö G, Szolcsányi J
机构信息
Department of Pharmacology, University Medical School of Pécs, Hungary.
出版信息
Acta Physiol Hung. 1996;84(3):331-2.
Electrical stimulation of the peripheral stump of the cut and perineurally capsaicin-pretreated saphenous nerve evokes antidromic vasodilatation preceded by a short vasoconstriction in the dorsal skin of the hindpaw in the rat. These microcirculatory changes were measured by laser-Doppler flowmetry. Blood flow increase induced by nerve stimulation was completely abolished by 1 microgram/kg resiniferatoxin (RTX), while the inicial blood flow decrease was significantly reduced or totally inhibited by subsequent treatments with an alpha adrenergic receptor antagonist (GYKI-12743) and a neuropeptide Y functional antagonist (alpha-trinositol) in response to 10 Hz and 3 HZ stimulations, respectively.
对切断且经神经周围辣椒素预处理的隐神经外周残端进行电刺激，可在大鼠后爪背部皮肤诱发逆向血管舒张，且在此之前有短暂的血管收缩。这些微循环变化通过激光多普勒血流仪进行测量。神经刺激诱导的血流增加被1微克/千克的树脂毒素（RTX）完全消除，而最初的血流减少在分别响应10赫兹和3赫兹刺激时，经α肾上腺素能受体拮抗剂（GYKI - 12743）和神经肽Y功能拮抗剂（α - 肌醇）后续处理后，显著减少或完全受到抑制。
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