Zhang D Q, Yang X L
Shanghai Institute of Physiology, Chinese Academy of Sciences.
Brain Res. 1997 Jun 6;759(1):160-2. doi: 10.1016/s0006-8993(97)00340-5.
This study examines the effect of gamma-aminobutyric acid (GABA) on the ON and OFF pathways in isolated, superfused carp retina. In most (76%) of amacrine cells bath-applied GABA preferentially suppressed the OFF response. The effect of GABA was blocked by bicuculline. Baclofen did not cause a similar effect. Furthermore, GABA produced a substantial suppression of the OFF bipolar cell response. We conclude that the preferential suppression of the OFF pathway may be due to a presynaptic inhibition mediated via GABA(A) receptors at the terminals of OFF bipolar cells.
本研究检测了γ-氨基丁酸（GABA）对离体、灌流的鲤鱼视网膜中开和关通路的作用。在大多数（76%）无长突细胞中，浴用GABA优先抑制关反应。GABA的作用被荷包牡丹碱阻断。巴氯芬未产生类似作用。此外，GABA对双极细胞的关反应产生了显著抑制。我们得出结论，关通路的优先抑制可能是由于双极细胞终末处通过GABA(A)受体介导的突触前抑制。
