Tourigny-Rivard M F
Department of Psychiatry, University of Ottawa, Ontario.
Can J Psychiatry. 1997 Jun;42 Suppl 1:10S-18S.
To present a clinical guide for the selection of safe and effective pharmacological treatment for depressed geriatric patients.
A review of the use of antidepressants in the elderly is presented based on clinical experience and a search of MEDLINE and PsychInfo data bases. Emphasis is placed on the following newer antidepressants: fluvoxamine, sertraline, paroxetine, nefazodone, venlafaxine, and moclobemide.
With the advent of newer antidepressants, physicians have been given a wider range of generally safer antidepressant medications. Although these medications appear to have favourable side effect profile in elderly patients, this review is limited because there are few published studies of the use of these newer antidepressants in the elderly.
Depression is a common psychiatric problem in old age, but it can usually be treated successfully. Although the use of antidepressants in geriatric populations is more likely to be complicated by poorly tolerated side effects and drug interactions than in younger patients, this review should help clinicians use currently available medications to the best advantage of their geriatric patients.
为老年抑郁症患者选择安全有效的药物治疗提供临床指南。
基于临床经验以及对MEDLINE和PsychInfo数据库的检索，对老年人使用抗抑郁药的情况进行综述。重点关注以下新型抗抑郁药：氟伏沙明、舍曲林、帕罗西汀、奈法唑酮、文拉法辛和吗氯贝胺。
随着新型抗抑郁药的出现，医生有了范围更广、总体上更安全的抗抑郁药物。尽管这些药物在老年患者中似乎具有良好的副作用特征，但由于关于这些新型抗抑郁药在老年人中使用的已发表研究较少，本综述存在局限性。
抑郁症是老年人常见的精神问题，但通常可以成功治疗。尽管与年轻患者相比，老年人群使用抗抑郁药更易出现耐受性差的副作用和药物相互作用，但本综述应有助于临床医生为老年患者充分利用现有药物。
