Bartolomeo P
INSERM Unité 324, Centre Paul Broca, Paris, France.
Cortex. 1997 Jun;33(2):323-32. doi: 10.1016/s0010-9452(08)70008-x.
Left neglect patients, patients who had recovered from left neglect and control subjects performed a task of simple motor reaction times (RTs) to lateralised visual stimuli. Neglect and recovered patients were slower than controls on left-sided targets. To explore the time course of the allocation of attention across space, an analysis of responses as a function of the serial order of the trials was performed. While neglect patients' performance did not substantially change over time, recovered patients showed a stereotyped 'novelty effect', consisting of larger left/right RT differences at the beginning of the task than at the end of it. To explain this practice-related change, a trade-off is hypothesised between the process of learning the motor task and the mechanisms involved in recovery from neglect, such as the reorienting of attention toward the contralesional side following the initial ipsilesional orienting. A possible role is proposed for the prefrontal cortex as the crucial neural structure that mediates both processes.
左侧忽视患者、已从左侧忽视中康复的患者以及对照组受试者执行了一项对侧化视觉刺激的简单运动反应时间（RT）任务。在左侧目标上，忽视患者和康复患者的反应比对照组慢。为了探究跨空间注意力分配的时间进程，对作为试验序列顺序函数的反应进行了分析。虽然忽视患者的表现随时间没有显著变化，但康复患者表现出一种刻板的“新奇效应”，即在任务开始时左右反应时间差异比任务结束时更大。为了解释这种与练习相关的变化，假设在学习运动任务的过程与从忽视中恢复所涉及的机制（如在最初向同侧定向后注意力重新定向到对侧）之间存在权衡。前额叶皮层被认为是介导这两个过程的关键神经结构，发挥了可能的作用。
