Green W B, Eaton K, Krakowka S
Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA.
Vet Immunol Immunopathol. 1997 May;56(1-2):119-31. doi: 10.1016/s0165-2427(96)05736-4.
The presence and features of mucosa associated lymhoid tissue (MALT), analogous to Peyer's patches, in the cardia of the lesser curvature of the porcine stomach are described. The gastric mucosa associated lymphoid tissue (gastric-MALT) is histologically distinct from gastric inflammation associated with colonization by normal gastric microflora and experimental bacterial colonization with a human gastric bacterial pathogen, Helicobacter pylori. The gastric-MALT consists of well-demarcated encapsulated and organized lymphoid tissue, intimately associated with overlying gastric epithelium, centered below the muscularis mucosae and drained by efferent lymphatics. Gastric-MALT was identified in all piglets studied including microbially sterile uninfected gnotobiotes; these structures were enlarged with age and local (gastric) antigenic stimulation. Significant (P < 0.05) expansion of the gastric-MALT occurred in H. pylori-infected gnotobiotic piglets. These distinct morphologic features and location in the cardia suggest that lymphoid elements in the gastric-MALT are involved in gastric antigen processing and regional lymphoid maturation, differentiation and proliferation in the stomach.
本文描述了猪胃小弯贲门处黏膜相关淋巴组织（MALT）的存在及其特征，该组织类似于派尔集合淋巴结。胃黏膜相关淋巴组织（gastric-MALT）在组织学上与正常胃微生物群定植以及人类胃细菌病原体幽门螺杆菌实验性细菌定植所引起的胃炎症不同。gastric-MALT由界限分明的被膜包裹且有组织的淋巴组织组成，与覆盖其上的胃上皮紧密相连，以黏膜肌层下方为中心，并由输出淋巴管引流。在所有研究的仔猪中均发现了gastric-MALT，包括无菌未感染的悉生动物；这些结构会随着年龄增长以及局部（胃）抗原刺激而增大。在幽门螺杆菌感染的悉生仔猪中，gastric-MALT出现了显著（P < 0.05）的扩张。这些独特的形态学特征以及在贲门处的位置表明，gastric-MALT中的淋巴成分参与了胃抗原处理以及胃中区域淋巴组织的成熟、分化和增殖。
