抗心律失常氨基甾体ORG 6001可降低犬冠状动脉闭塞所致的ST段抬高。
The antidysrhythmic aminosteroid, ORG 6001, reduces the ST-segment elevation produced by coronary occlusion in the dog.
作者信息
Marshall R J, Parratt J R
出版信息
Br J Pharmacol. 1977 Oct;61(2):315-7. doi: 10.1111/j.1476-5381.1977.tb08421.x.
Abstract
ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greatly reduced by the prior administration of the anti-dysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.
摘要
在开胸麻醉犬身上，从九条心外膜导联测量了冠状动脉暂时闭塞后的ST段抬高情况。抗心律失常氨基甾体ORG 6001预先给药可使这种情况大大减轻。提示这种作用要么与心肌缺血范围和程度的减轻有关，要么与防止缺血细胞的钾外流有关。
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