近端胃迷走神经切断术联合或不联合幽门成形术治疗单纯性十二指肠溃疡的前瞻性随机试验。
Prospectively randomised trial of proximal gastric vagotomy either with or without pyloroplasty in treatment of uncomplicated duodenal ulcer.
作者信息
Wastell C, Colin J, Wilson T, Walker E, Gleeson J, Zeegen R
出版信息
Br Med J. 1977 Oct 1;2(6091):851-3. doi: 10.1136/bmj.2.6091.851.
Abstract
A consecutive series of 100 men with uncomplicated duodenal ulcer was randomly divided into two groups: one group of 52 underwent proximal gastric vagotomy (PGV), the other group (48) underwent PGV with pyloroplasty (PGVP). Preoperative peak acid output (PAOP) was measured in all patients. Those with a higher preoperative PAOP were significantly more likely to develop recurrent ulceration. Three patients developed recurrent ulceration after PGV and seven after PGVP. Dumping was both more common and more severe after PGVP than PGV. An overall satisfactory result was achieved in 92% after PGV and 81% after PGVP. We conclude that combining pyloroplasty with PGV has no appreciable advantages.
摘要
连续选取100例单纯性十二指肠溃疡男性患者，随机分为两组：一组52例行近端胃迷走神经切断术（PGV），另一组48例行近端胃迷走神经切断术加幽门成形术（PGVP）。所有患者均测量术前高峰胃酸排量（PAOP）。术前PAOP较高的患者发生复发性溃疡的可能性显著更高。PGV术后有3例发生复发性溃疡，PGVP术后有7例发生。PGVP术后倾倒综合征比PGV术后更常见且更严重。PGV术后92%的患者获得总体满意结果，PGVP术后为81%。我们得出结论，将幽门成形术与PGV联合应用并无明显优势。
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