抗病毒细胞毒性T细胞反应的功能管理。
Functional management of an antiviral cytotoxic T-cell response.
作者信息
Bachmann M F, Speiser D E, Ohashi P S
机构信息
Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada.
出版信息
J Virol. 1997 Aug;71(8):5764-8. doi: 10.1128/JVI.71.8.5764-5768.1997.
Abstract
Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications.
摘要
淋巴细胞性脉络丛脑膜炎病毒（LCMV）已知可诱导强烈的多克隆细胞毒性T淋巴细胞（CTL）反应。我们使用一组源自LCMV主要CTL表位的变异肽，分析了LCMV特异性CTL反应的功能精细特异性。在初次反应期间，几乎所有测试肽都能被识别。相比之下，二次反应清除了所有轻微的交叉反应性，只有极少数肽能被显著识别。本研究首次证明了T细胞反应的功能成熟，具有重要的临床和生物学意义。
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本文引用的文献
1
Alternative pathways for the selection of antigen-specific peripheral T cells.选择抗原特异性外周T细胞的替代途径。
Nature. 1996 Nov 21;384(6606):263-6. doi: 10.1038/384263a0.
2
T cell responses are governed by avidity and co-stimulatory thresholds.T细胞反应受亲和力和共刺激阈值的调控。
Eur J Immunol. 1996 Sep;26(9):2017-22. doi: 10.1002/eji.1830260908.
3
Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.在一种病毒诱导的脱髓鞘疾病中选择出了细胞毒性T细胞抗性变体。
Immunity. 1996 Sep;5(3):253-62. doi: 10.1016/s1074-7613(00)80320-9.
4
On immunological memory.论免疫记忆。
Annu Rev Immunol. 1996;14:333-67. doi: 10.1146/annurev.immunol.14.1.333.
5
Mature T cell reactivity altered by peptide agonist that induces positive selection.肽激动剂诱导阳性选择改变成熟T细胞反应性。
J Exp Med. 1996 Mar 1;183(3):1093-104. doi: 10.1084/jem.183.3.1093.
6
Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones.体内抗原选择的T细胞受体库的单细胞PCR分析：高强度CD8反应由极少数克隆组成。
Immunity. 1996 Jan;4(1):47-55. doi: 10.1016/s1074-7613(00)80297-6.
7
Molecular analysis of T cell repertoires. Spectratypes generated by multiplex polymerase chain reaction and evaluated by radioactivity or fluorescence.T细胞受体库的分子分析。通过多重聚合酶链反应生成并通过放射性或荧光进行评估的谱型。
Hum Immunol. 1995 Sep;44(1):28-34. doi: 10.1016/0198-8859(95)00056-a.
8
Antigen-driven B cell differentiation in vivo.体内抗原驱动的B细胞分化
J Exp Med. 1993 Jul 1;178(1):295-307. doi: 10.1084/jem.178.1.295.
9
Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant.鉴定与来自主要组织相容性复合体I类结合决定簇的已知暴露肽侧链接触的保守T细胞受体CDR3残基。
Eur J Immunol. 1993 Dec;23(12):3318-26. doi: 10.1002/eji.1830231239.
10
Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells.细胞毒性表位的天然变体是抗病毒细胞毒性T细胞的T细胞受体拮抗剂。
Nature. 1994 Jun 2;369(6479):407-10. doi: 10.1038/369407a0.
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