Schwindt B, Doyle L W, Hutson J M
F. Douglas Stephens Surgical Research Laboratory, Royal Children's Hospital Research Foundation, Melbourne, Australia.
J Urol. 1997 Aug;158(2):610-2.
Müllerian inhibiting substance, also called anti-müllerian hormone, is responsible in the embryo for the regression of the müllerian structures. During the second and third trimesters the physiological functions that müllerian inhibiting substance may have after the period of müllerian duct regression are poorly understood. We obtained information on müllerian inhibiting substance levels in the male newborn during this period of gestation.
Müllerian inhibiting substance was measured by an enzyme immunoassay in cord blood obtained at birth in 27 preterm (25 to 36 weeks of gestation) and 92 term (37 to 42 weeks) male neonates.
Cord serum müllerian inhibiting substance concentrations were relatively high from 25 to 31 weeks (mean plus or minus standard deviation 86.4 +/- 36.1 ng./ml.) and then they decreased from 32 weeks to term (mean 24.2 +/- 14.0 ng./ml.).
The decline early in the third trimester may be consistent with müllerian inhibiting substance having a function during the second but a diminished role in the third trimester.
苗勒氏管抑制物质，也称为抗苗勒氏激素，在胚胎期负责苗勒氏结构的退化。在妊娠中期和晚期，对于苗勒氏管退化期之后苗勒氏管抑制物质可能具有的生理功能了解甚少。我们获取了妊娠该时期男婴新生儿苗勒氏管抑制物质水平的信息。
采用酶免疫分析法测定了27例早产（妊娠25至36周）和92例足月（妊娠37至42周）男婴出生时脐血中的苗勒氏管抑制物质。
脐血清苗勒氏管抑制物质浓度在25至31周时相对较高（均值±标准差86.4±36.1纳克/毫升），然后从32周降至足月时（均值24.2±14.0纳克/毫升）。
妊娠晚期早期的下降可能与苗勒氏管抑制物质在妊娠中期发挥作用但在晚期作用减弱相一致。
