AMP激活的蛋白激酶同工酶家族：亚基结构与染色体定位
AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.
作者信息
Stapleton D, Woollatt E, Mitchelhill K I, Nicholl J K, Fernandez C S, Michell B J, Witters L A, Power D A, Sutherland G R, Kemp B E
机构信息
St. Vincent's Institute of Medical Research, St. Vincent's Hospital, Fitzroy, Victoria, Australia.
出版信息
FEBS Lett. 1997 Jun 16;409(3):452-6. doi: 10.1016/s0014-5793(97)00569-3.
The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma (38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that rat liver AMPK-alpha2 isoform catalytic subunit is associated with beta1 and gamma1 and not with beta2 or gamma2 subunit isoforms. The beta1 and gamma1 isoforms are also subunits of the alpha1 isoform. The sequence of cloned human AMPK-beta1 is 95% identical in amino acid sequence with rat beta1. Human chromosomal localizations were determined for AMPK-alpha1 (5p11-p14), AMPK-beta1 (12q24.1-24.3) and AMPK-gamma1 (12q12-q14), respectively.
AMP 激活的蛋白激酶（AMPK）由催化性的α亚基和非催化性的β及γ（38 kDa）亚基组成，负责作为 AMP 水平的代谢传感器。每个亚基都有多个基因，我们发现大鼠肝脏 AMPK-α2 亚型催化亚基与β1 和γ1 相关，而与β2 或γ2 亚基亚型无关。β1 和γ1 亚型也是α1 亚型的亚基。克隆的人 AMPK-β1 的氨基酸序列与大鼠β1 的氨基酸序列有 95%的同一性。分别确定了人 AMPK-α1（5p11-p14）、AMPK-β1（12q24.1-24.3）和 AMPK-γ1（12q12-q14）在人染色体上的定位。
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