Consolo S, Ladinsky H, Bianchi S, Ghezzi D
Brain Res. 1977 Oct 28;135(2):255-63. doi: 10.1016/0006-8993(77)91029-0.
The nucleus accumbens septi and tuberculum olfactorium (NAS-TO), which from part of the mesolimbic dopaminergic system, and the striatum, which is part of the nigrostriatal dopamingeric system, contain high levels of both dopamine (DA) and acetylcholine and resemble each other in some other biochemical properties. We determined whether blockade or stimulation of DA receptors by agonists or antagonists affects the cholinergic neurons in this brain structure. The DA receptor antagonists haloperidol, pimozide, chlorpromazine and clozapine had no effect on the acetylcholine level in the NAS-TO even at 2-8 times the minimum dose required to maximally decrease striatal acetylcholine. Similarly, D-amphetamine and bromocriptine (CB 154), DA receptor stimulating drugs, had no effect on the acetylcholine level in this brain area at doses up to 3 times higher than those that produced a maximum increase in the striatum. Piribedil (15-120 mg/kg) and apomorphine (4 mg/kg) did increase acetylcholine in the NAS-TO but the action was not blocked by pimozide and is therefore not attributable to DA receptor action. The data thus indicate an apparent lack of a dopaminergic-cholinergic link in the NAS-TO.
伏隔核和嗅结节（NAS - TO）是中脑边缘多巴胺能系统的一部分，纹状体是黑质纹状体多巴胺能系统的一部分，它们都含有高水平的多巴胺（DA）和乙酰胆碱，并且在其他一些生化特性上彼此相似。我们确定了激动剂或拮抗剂对DA受体的阻断或刺激是否会影响该脑结构中的胆碱能神经元。DA受体拮抗剂氟哌啶醇、匹莫齐特、氯丙嗪和氯氮平即使在最大程度降低纹状体乙酰胆碱所需最小剂量的2 - 8倍时，对NAS - TO中的乙酰胆碱水平也没有影响。同样，DA受体激动剂右旋苯丙胺和溴隐亭（CB 154）在剂量高达比使纹状体中乙酰胆碱最大增加量的剂量高3倍时，对该脑区的乙酰胆碱水平也没有影响。匹立地尔（15 - 120毫克/千克）和阿扑吗啡（4毫克/千克）确实增加了NAS - TO中的乙酰胆碱，但该作用不受匹莫齐特阻断，因此不归因于DA受体作用。这些数据因此表明NAS - TO中明显缺乏多巴胺能 - 胆碱能联系。
