Hara Y, Ueta Y, Isse T, Kabashima N, Shibuya I, Hattori Y, Yamashita H
Department of Foods and Human Nutrition, Faculty of Human Life Sciences, Notre Dame Seishin University, Okayama, Japan.
Neurosci Lett. 1997 Jun 20;229(1):65-8. doi: 10.1016/s0304-3940(97)00419-9.
The effects of dehydration and food deprivation on urocortin-like immunoreactivity (Ucn-IR) in the rat supraoptic nucleus (SON) and the paraventricular nucleus (PVN) were examined by immunohistochemistry. Water deprivation for 48 h caused a significant increase in the number of Ucn-IR neurons in the SON, compared with control. Ucn-IR fibers and varicosities in the SON and the internal zone of the median eminence (ME) were increased, but a few and faint Ucn-IR neurons and fibers were observed in the PVN. On the other hand, food deprivation for 48 h caused a significant decrease in the number of Ucn-IR neurons in the SON, compared with control. Ucn-IR fibers and varicosities in the SON and the ME were fewer than those in controls. Ucn-IR neurons and fibers in the PVN were not detected after food deprivation. These results suggest that Ucn in the SON may be involved in the central regulation of water balance and nutrient homeostasis.
通过免疫组织化学方法研究了脱水和食物剥夺对大鼠视上核（SON）和室旁核（PVN）中尿皮质素样免疫反应性（Ucn-IR）的影响。与对照组相比，48小时禁水导致SON中Ucn-IR神经元数量显著增加。SON和正中隆起（ME）内侧区的Ucn-IR纤维和膨体增多，但在PVN中观察到少量且微弱的Ucn-IR神经元和纤维。另一方面，与对照组相比，48小时禁食导致SON中Ucn-IR神经元数量显著减少。SON和ME中的Ucn-IR纤维和膨体比对照组少。禁食后未检测到PVN中的Ucn-IR神经元和纤维。这些结果表明，SON中的Ucn可能参与水平衡和营养稳态的中枢调节。
