Bates D, Weinshilboum R M, Campbell R J, Sundt T M
Brain Res. 1977 Nov 18;136(3):431-43. doi: 10.1016/0006-8993(77)90068-3.
The effects of cerebral blood flow (CBF) of lesions placed stereotactically in or near the locus coeruleus were studied in 15 lightly anesthetized cats; 5 control cats in which the electrode was placed but no lesion created, and 10 experimental cats in which a lesion was created. The response of CBF to changes in Paco2 and in mean arterial blood pressure was determined by 133Xe-washout studies 10 days after the stereotactic procedures. The sites of the lesions were studied histologically, and their effects on catecholamine concentrations in the paraventricular hypothalamic nucleus, anterior ventral nucleus of the thalamus, and parietal cortex were determined by radio-chemical assay. Control animals and those with lesions near, but not in, the locus coeruleus had normal Paco2--CBF response curves and normal catecholamine concentrations in the areas of biopsy. Bilateral destruction of the locus coeruleus was confirmed in 3 animals on histological examination and in these animals there were decreased levels of catecholamines in the areas of assay, higher resting CBFs at normocapnia, and significantly abnormal CBF--Paco2 response curves. The autoregulatory response to changes in perfusion pressure was preserved. Thus, noradrenergic neurons originating in the locus coeruleus may contribute to the control of intraparenchymal cerebral vessels and disturbance of this control may be important in the pathology of cerebral ischemia.
在15只轻度麻醉的猫身上研究了立体定向放置在蓝斑核内或其附近的病变对脑血流量（CBF）的影响；5只对照猫，电极已放置但未造成损伤，10只实验猫，造成了损伤。在立体定向手术10天后，通过133Xe洗脱研究确定了CBF对动脉血二氧化碳分压（Paco2）和平均动脉血压变化的反应。对病变部位进行了组织学研究，并通过放射化学分析确定了它们对下丘脑室旁核、丘脑前腹核和顶叶皮质中儿茶酚胺浓度的影响。对照动物以及病变位于蓝斑核附近但不在蓝斑核内的动物，其Paco2 - CBF反应曲线正常，活检区域的儿茶酚胺浓度正常。在3只动物的组织学检查中证实了双侧蓝斑核破坏，在这些动物中，测定区域的儿茶酚胺水平降低，正常碳酸血症时静息CBF较高，且CBF - Paco2反应曲线明显异常。对灌注压变化的自动调节反应得以保留。因此，起源于蓝斑核的去甲肾上腺素能神经元可能有助于控制脑实质内血管，这种控制的紊乱在脑缺血病理过程中可能很重要。
