Yoshihara T, Nagai K
Department of Otolaryngology, Tokyo Women's Medical College, Japan.
Int J Pediatr Otorhinolaryngol. 1997 Jun 20;40(2-3):181-7. doi: 10.1016/s0165-5876(97)00026-8.
A rare case of a 5-year-old female with schwannoma of the maxillary sinus is presented. She had complained of painless swelling of the left cheek and hard palate for a duration of one year. Preoperatively, a CT scan strongly suggested it to be a maxillary cyst with an erupted tooth rather than neoplasm. The tumour was completely removed after embolization of the left internal maxillary artery. The tumour was composed of spindle cells in a palisading pattern and intercellular collagenous fibres. Mitotic figures and atypical nuclei were not observed. Immunohistochemically, the majority of the cells were positive for NSE and S-100 protein, whereas GFA and PCNA showed little immunoreaction. The pathological diagnosis was Antony type A of schwannoma arising in the maxillary sinus.
本文报告了一例罕见的5岁女性上颌窦神经鞘瘤病例。她主诉左侧脸颊和硬腭无痛性肿胀已持续一年。术前，CT扫描强烈提示为伴有萌出牙的上颌囊肿而非肿瘤。在对上颌内动脉进行栓塞后，肿瘤被完全切除。肿瘤由呈栅栏状排列的梭形细胞和细胞间胶原纤维组成。未观察到有丝分裂象和非典型核。免疫组织化学检查显示，大多数细胞NSE和S-100蛋白呈阳性，而GFA和PCNA几乎无免疫反应。病理诊断为上颌窦发生的Antony A型神经鞘瘤。
