一匹荷兰温血母马的单克隆丙种球蛋白病

Monoclonal gammopathy in a Dutch warmblood mare.

作者信息

Geelen S N, Bernadina W E, Grinwis G C, Kalsbeek H C

机构信息

Department of Large Animal Medicine and Nutrition, Utrecht University, Faculty of Veterinary Medicine, The Netherlands.

出版信息

Vet Q. 1997 Mar;19(1):29-32. doi: 10.1080/01652176.1997.9694734.

DOI:10.1080/01652176.1997.9694734

PMID:9225427

Abstract

A 15-year-old Dutch warmblood mare was presented because of lethargy, which had been present for several weeks, and severe anaemia. Total protein was high and serum electrophoresis revealed a monoclonal peak in the alpha-2 region. Monoclonal immunoglobulin, IgG(T), was detected by immuno-electrophoresis in serum and urine. Postmortem examination revealed a relatively large number of plasmacytoid cells in the bone marrow and a monotonous population of plasmacytoid cells in the spleen. These findings are suggestive of a plasma cell myeloma.

摘要

一匹15岁的荷兰温血母马因嗜睡（已持续数周）和严重贫血前来就诊。总蛋白水平升高，血清电泳显示α-2区域有一个单克隆峰。通过免疫电泳在血清和尿液中检测到单克隆免疫球蛋白IgG(T)。尸检发现骨髓中有相对大量的浆细胞样细胞，脾脏中有单一类型的浆细胞样细胞。这些发现提示为浆细胞骨髓瘤。