磺胺二甲氧嘧啶在犬体内的生物利用度、处置动力学及剂量——勘误
Bioavailability, disposition kinetics and dosage of sulfadimethoxine in dogs--a correction.
作者信息
Sams R A, Baggot J D
出版信息
Can J Comp Med. 1977 Oct;41(4):479-80.
Abstract
A reevaluation of the disposition kinetics and extent of absorption of sulfadimethoxine in normal dogs following intravenous and oral dosage has been made. The tissue to plasma level ratio at the peak tissue level (k12/k21) was 0.55, while the tissue to plasma level ratio after distribution equilibrium (k12/k21-beta) was 0.926. The systemic availability of sulfadimethoxine from the oral suspension was 48.8% (24.4-86.2) when corrections for intrasubject variability were made.
摘要
对正常犬静脉注射和口服磺胺二甲氧嘧啶后的处置动力学和吸收程度进行了重新评估。在组织浓度峰值时的组织与血浆浓度比（k12/k21）为0.55，而分布平衡后的组织与血浆浓度比（k12/k21-β）为0.926。当对受试者内变异性进行校正后，口服混悬液中磺胺二甲氧嘧啶的全身可用性为48.8%（24.4 - 86.2）。
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本文引用的文献
1
The bioavailability, dispostion kinetics and dosage of sulphadimethoxine in dogs.磺胺二甲氧嘧啶在犬体内的生物利用度、处置动力学及剂量
Can J Comp Med. 1976 Jul;40(3):310-7.
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