Ament P W, Paterson A
Latrobe Area Hospital, Pennsylvania, USA.
Am Fam Physician. 1997 Jul;56(1):223-31.
The nonsedating antihistamines are frequently prescribed agents. Well-documented drug-drug interactions with two of these agents, terfenadine and astemizole, may result in serious adverse effects, including death, when they are prescribed along with macrolide antibiotics and/or the antifungal agents itraconazole or ketoconazole. Fexofenadine and loratadine appear to be the least likely nonsedating antihistamines to interact with other medications and to result in a life-threatening interaction. This article reviews the known drug-drug interactions involving nonsedating antihistamines and provides a basis from which the clinician can predict potential interactions.
非镇静性抗组胺药是常用药物。其中两种药物特非那定和阿司咪唑有充分文献记载的药物相互作用，当它们与大环内酯类抗生素和/或抗真菌药伊曲康唑或酮康唑合用时，可能会导致严重不良反应，包括死亡。非索非那定和氯雷他定似乎是与其他药物相互作用可能性最小且不会导致危及生命相互作用的非镇静性抗组胺药。本文综述了已知的涉及非镇静性抗组胺药的药物相互作用，并为临床医生预测潜在相互作用提供了依据。
