蜂毒明肽敏感的钙激活钾通道在大鼠快、慢肌中的年龄依赖性表达

Age-dependent expression of the apamin-sensitive calcium-activated K+ channel in fast and slow rat skeletal muscle.

作者信息

Vergara C, Ramirez B U

机构信息

Facultad de Ciencias, Universidad de Chile, Santiago, Chile.

出版信息

Exp Neurol. 1997 Jul;146(1):282-5. doi: 10.1006/exnr.1997.6486.

DOI:10.1006/exnr.1997.6486

PMID:9225762

Abstract

An altered expression of the apamin-sensitive K+ channel from skeletal muscle is apparently implicated in human myotonic dystrophy (MD). We found, in rats, that the expression of this channel depends on age and the type of muscle. This result may be one of the bases of the different susceptibilities of fast and slow muscles to drug-induced myotonia.

摘要

骨骼肌中蜂毒明肽敏感钾通道的表达改变显然与人类强直性肌营养不良（MD）有关。我们发现，在大鼠中，该通道的表达取决于年龄和肌肉类型。这一结果可能是快肌和慢肌对药物诱导的肌强直敏感性不同的基础之一。