Mahmood T, Devlin M, Silverstone T
Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, New Zealand.
Aust N Z J Psychiatry. 1997 Jun;31(3):424-6. doi: 10.3109/00048679709073854.
To test the efficacy of clozapine in treatment-resistant manic episodes.
Three cases, two with bipolar disorder (manic) and one of schizoaffective disorder (manic), were treated with clozapine.
Clozapine was used after the failure of standard antipsychotics and mood stabilizers.
All three cases were successfully treated.
A controlled trial of clozapine in treatment-resistant bipolar and schizoaffective manic episodes is indicated.
测试氯氮平治疗难治性躁狂发作的疗效。
3例患者，2例为双相情感障碍（躁狂型），1例为分裂情感性障碍（躁狂型），接受了氯氮平治疗。
在标准抗精神病药物和心境稳定剂治疗失败后使用氯氮平。
所有3例患者均成功治愈。
有必要对氯氮平治疗难治性双相情感障碍和分裂情感性躁狂发作进行对照试验。
