Eisenberg V H, Schenker J G
Department of OBstetrics and Gynecology, Hadassah University Medical Center, Ein-Karem, Jerusalem, Israel.
J Assist Reprod Genet. 1997 Jul;14(6):297-316. doi: 10.1007/BF02765833.
Present-day scientific advances have made it possible to use somatic cell gene therapy for the treatment of serious human genetic disease. Gene therapy is enormously important for curing some diseases, otherwise untreatable. The technical ability to perform germline gene alteration is also under way. Society must determine its attitude toward germline alteration and toward intervention for the purpose of genetic enhancement. Eugenic genetics is purely theoretical at present and is likely to remain so for a long time. Articles in the press, sometimes influenced by specific pressure groups, generate public fear that is in most cases unfounded, due to the lack of feasibility of performing the claims voiced in them. Still, society must be concerned about the possibility that gene therapy will be misused in the future. Gene therapy should only be used in ways that maintain human dignity. The best insurance against misuse is a public well informed and not unnecessarily frightened. With proper safeguards imposed by society, gene therapy can be ethically used.
当今的科学进步使得利用体细胞基因疗法治疗严重的人类遗传疾病成为可能。基因疗法对于治愈某些原本无法治疗的疾病极为重要。进行生殖系基因改造的技术能力也正在发展之中。社会必须确定其对生殖系改造以及为基因增强目的而进行干预的态度。优生遗传学目前纯粹是理论上的,而且很可能在很长一段时间内都将如此。媒体上的文章有时受到特定压力团体的影响,引发公众的恐惧,而在大多数情况下,这种恐惧是毫无根据的,因为这些文章中所宣称的内容缺乏可行性。尽管如此,社会必须关注基因疗法未来可能被滥用的可能性。基因疗法的使用方式应维护人类尊严。防止滥用的最佳保障是让公众充分了解情况且不过度恐慌。在社会施加适当的保障措施的情况下,基因疗法可以在伦理层面上得到应用。