Suppr超能文献

基因工程:道德层面与实践管控

Genetic engineering: moral aspects and control of practice.

作者信息

Eisenberg V H, Schenker J G

机构信息

Department of OBstetrics and Gynecology, Hadassah University Medical Center, Ein-Karem, Jerusalem, Israel.

出版信息

J Assist Reprod Genet. 1997 Jul;14(6):297-316. doi: 10.1007/BF02765833.

Abstract

Present-day scientific advances have made it possible to use somatic cell gene therapy for the treatment of serious human genetic disease. Gene therapy is enormously important for curing some diseases, otherwise untreatable. The technical ability to perform germline gene alteration is also under way. Society must determine its attitude toward germline alteration and toward intervention for the purpose of genetic enhancement. Eugenic genetics is purely theoretical at present and is likely to remain so for a long time. Articles in the press, sometimes influenced by specific pressure groups, generate public fear that is in most cases unfounded, due to the lack of feasibility of performing the claims voiced in them. Still, society must be concerned about the possibility that gene therapy will be misused in the future. Gene therapy should only be used in ways that maintain human dignity. The best insurance against misuse is a public well informed and not unnecessarily frightened. With proper safeguards imposed by society, gene therapy can be ethically used.

摘要

当今的科学进步使得利用体细胞基因疗法治疗严重的人类遗传疾病成为可能。基因疗法对于治愈某些原本无法治疗的疾病极为重要。进行生殖系基因改造的技术能力也正在发展之中。社会必须确定其对生殖系改造以及为基因增强目的而进行干预的态度。优生遗传学目前纯粹是理论上的,而且很可能在很长一段时间内都将如此。媒体上的文章有时受到特定压力团体的影响,引发公众的恐惧,而在大多数情况下,这种恐惧是毫无根据的,因为这些文章中所宣称的内容缺乏可行性。尽管如此,社会必须关注基因疗法未来可能被滥用的可能性。基因疗法的使用方式应维护人类尊严。防止滥用的最佳保障是让公众充分了解情况且不过度恐慌。在社会施加适当的保障措施的情况下,基因疗法可以在伦理层面上得到应用。

相似文献

1
Genetic engineering: moral aspects and control of practice.
J Assist Reprod Genet. 1997 Jul;14(6):297-316. doi: 10.1007/BF02765833.
2
Scientific and ethical considerations in human gene therapy.
Baillieres Clin Obstet Gynaecol. 1991 Sep;5(3):697-713. doi: 10.1016/s0950-3552(05)80265-2.
3
Gene therapy and genetic alteration.
Hum Gene Ther. 1994 May;5(5):603-14. doi: 10.1089/hum.1994.5.5-603.
4
The new gene technology and the difference between getting rid of illness and altering people.
Eur J Genet Soc. 1995;1(1):12-20. doi: 10.1179/hrge.1.1.276042718403jh80.
5
Reprogenetics policy: three kinds of models.
Community Genet. 1998;1(2):61-70. doi: 10.1159/000016139.
6
Commentary: maintaining the somatic/germ-line distinction: some ethical drawbacks.
J Med Philos. 1991 Dec;16(6):641-7. doi: 10.1093/jmp/16.6.641.
7
Genetic enhancement in humans.
Science. 1999 Mar 26;283(5410):2023-4. doi: 10.1126/science.283.5410.2023.
8
Altering human genes: social, ethical, and legal implications.
Perspect Biol Med. 1994 Summer;37(4):566-75. doi: 10.1353/pbm.1994.0083.
9
Germ-line gene therapy: no place in treatment of genetic disease.
Hum Gene Ther. 1994 Feb;5(2):151-2. doi: 10.1089/hum.1994.5.2-151.
10
Germ-line engineering: a few European voices.
J Med Philos. 1991 Dec;16(6):649-66. doi: 10.1093/jmp/16.6.649.

本文引用的文献

3
Genetical implications of the structure of deoxyribonucleic acid.
Nature. 1953 May 30;171(4361):964-7. doi: 10.1038/171964b0.
4
Genetic exchange in Salmonella.
J Bacteriol. 1952 Nov;64(5):679-99. doi: 10.1128/jb.64.5.679-699.1952.
5
National and international approaches to human germ-line gene therapy.
Politics Life Sci. 1994 Feb;13(1):39-49. doi: 10.1017/s0730938400022206.
6
Bioethics in medically assisted conception in the Muslim world.
J Assist Reprod Genet. 1995 Oct;12(9):559-65. doi: 10.1007/BF02212574.
7
Gene inoculation generates immune responses against human immunodeficiency virus type 1.
Proc Natl Acad Sci U S A. 1993 May 1;90(9):4156-60. doi: 10.1073/pnas.90.9.4156.
8
Regulation of somatic-cell therapy and gene therapy by the food and drug administration.
N Engl J Med. 1993 Oct 14;329(16):1169-73. doi: 10.1056/NEJM199310143291607.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验