Therapeutic relevance of differences in the structural specificity of the transport systems for folate analogs in L1210 tumor cells and in isolated murine intestinal epithelial cells. - Suppr | 超能文献

Therapeutic relevance of differences in the structural specificity of the transport systems for folate analogs in L1210 tumor cells and in isolated murine intestinal epithelial cells.

作者信息

Chello P L, Sirotnak F M, Dorick D M, Donsbach R C

出版信息

Cancer Res. 1977 Dec;37(12):4297-303.

Abstract

摘要

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Therapeutic relevance of differences in the structural specificity of the transport systems for folate analogs in L1210 tumor cells and in isolated murine intestinal epithelial cells.

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Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.与小鼠小肠不同成熟阶段上皮细胞中二氢叶酸还原酶水平的变化形成对比的是，体外叶酸类似物转运具有相似的特征。

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Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.体外培养的人源和鼠源肿瘤细胞中各种叶酸类似物的总多聚谷氨酰化及细胞毒性的类似差异。

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New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties.10-脱氮氨基蝶呤系列的新型叶酸类似物。结构设计基础以及生化和药理特性

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Selective uptake and retention of anticancer agents by sensitive cells.敏感细胞对抗癌药物的选择性摄取和保留。

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