Seymen O, Seven A, Candan G, Yigit G, Hatemi S, Hatemi H
Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
Acta Med Okayama. 1997 Jun;51(3):129-33. doi: 10.18926/AMO/30797.
Our aim was to study the effect of iron supplementation on the following aspects of erythrocyte metabolism in experimental hyperthyroidism: glutathione (GSH) levels, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities. Hyperthyroidism induced by L-thyroxine administrations significantly raised erythrocyte GSH, GSH-Px and SOD levels of the rats (P < 0.001). Likewise, we observed that iron supplementation induced significant rises in erythrocyte GSH, GSH-Px and SOD levels (P < 0.001) as compared with the control group. The erythrocyte GSH, GSH-Px and SOD levels of hyperthyroidism-induced iron-supplemented animals were significantly higher when compared with either the iron-supplemented group (P < 0.001) or the only L-thyroxine-administered hyperthyroid group (P < 0.001, P < 0.05, P < 0.01, respectively). The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH, GSH-Px and SOD levels of erythrocytes.
谷胱甘肽（GSH）水平、谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶（SOD）活性。给予L-甲状腺素诱导的甲状腺功能亢进症显著提高了大鼠红细胞GSH、GSH-Px和SOD水平（P<0.001）。同样，我们观察到与对照组相比，补充铁显著提高了红细胞GSH、GSH-Px和SOD水平（P<0.001）。与单纯补充铁的组（P<0.001）或仅给予L-甲状腺素的甲状腺功能亢进组相比（分别为P<0.001、P<0.05、P<0.01），甲状腺功能亢进诱导的补充铁动物的红细胞GSH、GSH-Px和SOD水平显著更高。本研究结果表明，给予L-甲状腺素和/或补充铁会增加红细胞的GSH、GSH-Px和SOD水平。
