Levin K H
Department of Neurology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Neurol Clin. 1997 Aug;15(3):597-614. doi: 10.1016/s0733-8619(05)70336-4.
Although paraneoplastic syndromes are rare, a number of well- defined, neuromuscular paraneoplastic syndromes have been described and their pathophysiology listed. Many different malignancies have been associated with these syndromes, but small-cell lung cancer is the most common. Features shared by these conditions include onset of the underlying malignancy, rapid progression, severe disability, and the potential for some improvement, owing to treatment of the cancer. This article discusses Lambert-Eaton myasthenic syndrome, motor neuron disorders, peripheral neuropathies, and disorders of continuous muscle fiber activity, such as Stiffman syndrome.
虽然副肿瘤综合征很罕见，但已经描述了一些明确的神经肌肉副肿瘤综合征，并列出了它们的病理生理学。许多不同的恶性肿瘤都与这些综合征有关，但小细胞肺癌是最常见的。这些病症的共同特征包括潜在恶性肿瘤的发病、快速进展、严重残疾以及由于癌症治疗而有一定改善的可能性。本文讨论兰伯特-伊顿肌无力综合征、运动神经元疾病、周围神经病变以及连续肌肉纤维活动障碍，如僵人综合征。
