Cranney A, Markman S, Lach B, Karsh J
Division of Hematology, Ottawa Civic Hospital, Canada.
J Rheumatol. 1997 Jul;24(7):1413-6.
A patient presenting with agranulocytosis and lymphocytosis (4600/mm3) was found subsequently to have polymyositis (PM) and a thymoma. Immunophenotyping of the circulating lymphocytes revealed mature T cells (CD3, CD5, CD7 positive) with normal proportions of both CD4 (55%) and CD8 (38%) positive cells. PM was confirmed by electromyogram and muscle biopsy. Fewer than a dozen cases of thymoma and T cell lymphocytosis have been reported and ours is the first in which autoimmune manifestations have been noted. The presence of lymphocytosis in a patient with PM should prompt the search for a thymoma.
一名出现粒细胞缺乏症和淋巴细胞增多（4600/mm³）的患者随后被诊断患有多发性肌炎（PM）和胸腺瘤。循环淋巴细胞的免疫表型分析显示为成熟T细胞（CD3、CD5、CD7阳性），CD4阳性细胞（55%）和CD8阳性细胞（38%）比例正常。通过肌电图和肌肉活检确诊为PM。据报道，胸腺瘤合并T细胞淋巴细胞增多的病例不到12例，我们的病例是首例发现有自身免疫表现的。PM患者出现淋巴细胞增多应促使医生寻找胸腺瘤。
