Carrell R W, Lomas D A
Department of Haematology, University of Cambridge, MRC Centre, Addenbrooke's Hospital, UK.
Lancet. 1997 Jul 12;350(9071):134-8. doi: 10.1016/S0140-6736(97)02073-4.
Several diverse disorders, including the prevalent dementias and encephalopathies, are now believed to arise from the same general disease mechanism. In each, there is abnormal unfolding and then aggregation of an underlying protein. The gradual accumulation of these aggregates and the acceleration of their formation by stress explain the characteristic late or episodic onset of the clinical disease. The understanding of these processes at the molecular level is opening prospects of more rational approaches to investigation and therapy.
现在认为，包括常见的痴呆症和脑病在内的几种不同疾病都源于相同的一般疾病机制。在每种疾病中，都存在一种潜在蛋白质的异常展开然后聚集的情况。这些聚集体的逐渐积累以及应激对其形成的加速作用解释了临床疾病典型的晚期或发作性发作。在分子水平上对这些过程的理解为更合理的研究和治疗方法开辟了前景。
