Leroux C, Chastang J, Greenland T, Mornex J F
Laboratoire d'Immunologie et de Biologie Pulmonaire, Hôpital Louis Pradel, Lyon, France.
Arch Virol. 1997;142(6):1125-37. doi: 10.1007/s007050050147.
We have recently shown that French small ruminant lentiviruses (SRLV) from sheep are more similar to Caprine Arthritis Encephalitis Virus (CAEV) than to visna maedi virus (VMV) in a conserved region of the pol gene. To extend these results, we have examined sequences from a variable region of the env gene in French SRLV. We found that they were nearly equally distant from both CAEV and VMV strains, suggesting a considerable divergence since the initial introduction of the virus. Analysis of separate clones from individual animals showed that some carry a population of variant viruses. The study of further pol gene sequences from both goats and sheep suggests that viral variants show little or no host species specificity. A phylogenetic tree of pol gene sequences confirmed the presence of a novel genotype of SRLV in France.
我们最近发现，在pol基因的一个保守区域，来自法国绵羊的小型反刍动物慢病毒（SRLV）与山羊关节炎脑炎病毒（CAEV）的相似性高于梅迪-维斯纳病毒（VMV）。为了扩展这些结果，我们检测了法国SRLV env基因可变区域的序列。我们发现它们与CAEV和VMV毒株的距离几乎相等，这表明自病毒最初引入以来发生了相当大的分化。对来自个体动物的单独克隆进行分析表明，有些携带了一群变异病毒。对来自山羊和绵羊的更多pol基因序列的研究表明，病毒变异体几乎没有宿主物种特异性。pol基因序列的系统发育树证实了法国存在一种新型的SRLV基因型。
