Storch M, Lassmann H
Institute of Neurology, University of Vienna, Austria.
Curr Opin Neurol. 1997 Jun;10(3):186-92. doi: 10.1097/00019052-199706000-00004.
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system of putative autoimmune origin. In the present review the hypothesis that autoimmunity against multiple different brain antigens can lead to T-cell mediated brain inflammation and that multiple different immunological mechanisms may be responsible for the destruction of myelin is highlighted. The multitude of possible pathogenetic mechanisms is reflected in multiple sclerosis patients by a broad spectrum of disease susceptibility genes and by a profound heterogeneity of pathology and immunopathogenesis of the lesions.
多发性硬化症是一种假定为自身免疫起源的中枢神经系统炎性脱髓鞘疾病。在本综述中，强调了针对多种不同脑抗原的自身免疫可导致T细胞介导的脑部炎症，以及多种不同免疫机制可能导致髓鞘破坏的假说。多种可能的致病机制在多发性硬化症患者中表现为广泛的疾病易感基因谱以及病变病理和免疫发病机制的显著异质性。
